So yesterday I felt like crap pretty much all day. I was hoping that it was the Estrace and PIL getting out of my system, not MS rebooting.
Nope, turns out I just forgot to take my B6. In my head I was thinking "no meds, woot!" and so I just didn't take anything that morning- including B6.
Luckily I take my prentals at night. When I take those, I take my B6 and unisom (and up until Tuesday, Estrace) so I remembered last night.
Lesson learned. I took the B6 as soon as I was out of bed this morning.